Categoria: Articoli in lingua originale

A new bioengineered, miniature organ dubbed the BioHub might one day offer people with type 1 diabetes freedom from their disease. In its final stages, the BioHub would mimic a pancreas and act as a home for transplanted islet cells, providing them with oxygen until they could establish their own blood

Exposure to maternal diabetes during pregnancy appears to influence the development of type 2 diabetes in children, according to recent data from the TODAY trial. Steven D. Chernausek, MD, from the department of pediatrics at the University of Oklahoma Health Sciences Center in Oklahoma City, and colleagues found that maternal

Paul S. Mueller, MD, MPH, FACP Reviewing Lind M et al., BMJ 2015 Oct 28; 351:h5364 Adding liraglutide also facilitated weight loss and lowered insulin doses. The injectable glucagon-like peptide-1–receptor agonist liraglutide (Victoza) improves glycemic control in patients with type 2 diabetes who are treated with oral antidiabetic drugs or basal insulin

Allan S. Brett, MD reviewing Jakubowicz D et al. Diabetes Care 2015 Oct. In this study, having no breakfast was associated with higher blood glucose after lunch and dinner. Skipped meals complicate management of insulin-treated diabetic patients. A new study suggests that skipping breakfast might affect glycemic control even in patients who are not

Epidemiological data suggesting an infectious origin of diabetes pre-date the discovery of insulin; indeed it was the variation in mortality rates from diabetes that led Gunderson to hypothesise that a virus with ‘selective affinity for the pancreas’ may cause ‘acute diabetes’ in youth (1). He noted an increase in deaths

In a recent randomized trial, the diabetes drug saxagliptin (Onglyza; a dipeptidyl peptidase (DPP)-4 inhibitor) was associated with a modest but statistically significant increase in hospital admissions for heart failure (NEJM JW Gen Med Oct 1 2013 and N Engl J Med 369:1317). Now, industry-supported researchers have examined the cardiovascular safety

Details of a large heart safety study presented on Monday appear to give Merck and Co’s diabetes drug Januvia a clean bill of health, possibly setting the stage for a return to sales growth for the drugmaker’s biggest product. Merck in April said the study, called Tecos, of 14,724 patients

Patients with type-2 diabetes who are overweight but not obese outlive diabetics of normal weight, scientists reported on Monday, in another example of the “obesity paradox.” Although public health officials issue dire warnings about the consequences of overweight, and employers are pressuring workers to slim down via “wellness programs,” the

In the landmark ACCORD trial (NEJM JW Gen Med Jul 1 2008 and N Engl J Med 2008; 358:2545), which involved >10,000 patients with longstanding type 2 diabetes, all-cause and cardiovascular-related mortality were significantly higher in patients randomized to intensive glycemic control (target glycosylated hemoglobin [HbA1c], <6%) than in those who